29 RESULTS
Go to another page:
COMMENT John was a wonderful and talented scientist who challenged all of us in the field to do the best science possible. He, along with Virginia, was very committed to identifying the key pathological events leading to Alzheimer's and other neurodegenerati
COMMENT The publication by Peter Davies and A.J. Maloney in The Lancet (1976) describing the selective loss of central cholinergic neurons in autopsy-verified cases of Alzheimer’s disease provided much of the scientific motivation to test the effects of cholinest
COMMENT This paper provides additional support for the growing body of data indicating that neuronal overactivity in the medial temporal regions of the brain are an integral part of the pathophysiology of early Alzheimer’s disease and probably play a role in driv
COMMENT Advances in PET imaging, particularly development of radioligands binding to biologically important sites, has helped with major advances in clinical neuroscience research. This paper shows what appears to be the first radioligand to bind to sites at syna
COMMENT This is an interesting study presenting data linking higher plasma levels of amyloid β1-40 with small vessel disease in patients with acute stroke. The role of Aβ in cerebrovascular disease has been of interest for some time, and these data suggest that s
COMMENT This is an interesting paper that adds additional information about the value of multiple biomarkers as predictors of future decline in older persons. Specifically, CSF pTau predicted subsequent hippocampal atrophy independent of baseline atrophy and cogn
COMMENT This study provides support for one hypothesis about the way in which APOE can influence the development of Alzheimer disease. 0 MOHS_RICHARD
COMMENT This new analysis of the ways in which mutations known to cause familial AD influence the processing of amyloid beta will help understand the role of amyloid beta in causing this disease. 0 MOHS_RICHARD
COMMENT Timely paper which uses data from the CATIE-AD trial to illustrate how cost-effectiveness analyses can be done to explore the relationship of clinical benefit to cost. Similar analyses are likely to be applied to drugs introduced for AD and other neurodeg
COMMENT Conditions under which an abnormality in tau processing could lead to neuronal degeneration are of great interest because of their potential implications for the role of tau in human neurodegenerative disease. This paper describes one set of conditions in
COMMENT This case-control study using information from over 10,000 patients in an administrative claims database of commercial health insurers provides good information on medical comorbidities, hospitalizations, and fractures among AD patients relative to matche
COMMENT This paper presents interesting longitudinal data from the Alzheimer's Disease Neuroimaging (ADNI) cohort. The data from FDG-PET imaging, cognitive testing and functional assessment help elucidate the sequence of events which occur in brain and in sy
COMMENT For those interested in biomarkers that may enhance the identification and classification of patients with Alzheimer disease and prodromal AD, CSF studies are quite important. This paper describes techniques that increase the acceptability of such studies
COMMENT This is an interesting population-based study correlating neuropathologic findings with dementia. It demonstrates that these relationships are generally stronger in younger old persons that in the oldest old. 0 MOHS_RICHARD
COMMENT The predictive value of amyloid deposits in persons without frank dementia continues to be an area of intense research interest. This study of amyloid PET imaging in persons with Mild Cognitive Impairment (MCI) is an important contribution. If these resul
Go to another page:
